^99mTc-labelled biphosphonates

Clinical Evaluation	Osteoblastic activity
Type of Imaging	Scintigraphy
Grade of Recommendation	A (strongly recommended)
Level of Evidence	well-designed NM recommendations
Effective Dose	4.9 µSv/MBq
Bibliographic Reference	Singer, F. R., Bone, H. G., 3rd, Hosking, D. J., Lyles, K. W., Murad, M. H., Reid, I. R., et al. Paget's disease of bone: an Endocrine Society clin... read more Singer, F. R., Bone, H. G., 3rd, Hosking, D. J., Lyles, K. W., Murad, M. H., Reid, I. R., et al. Paget's disease of bone: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014 https://doi.org/10.1210/jc.2014-2910 Van den Wyngaert, T., Strobel, K., Kampen, W. U., Kuwert, T., van der Bruggen, W., Mohan, H. K., et al. The EANM practice guidelines for bone scintigraphy. Eur J Nucl Med Mol Imaging. 2016; https://doi.org/10.1007/s00259-016-3415-4 read less
Guide to Nuclear Medicine	Read the corresponding chapter

Clinical Evaluation
Osteoblastic activity
Type of Imaging
Scintigraphy
Grade of Recommendation
A (strongly recommended)
Level of Evidence
well-designed NM recommendations
Effective Dose
4.9 µSv/MBq
Bibliographic Reference
Singer, F. R., Bone, H. G., 3rd, Hosking, D. J., Lyles, K. W., Murad, M. H., Reid, I. R., et al. Paget's disease of bone: an Endocrine Society clin... read more Singer, F. R., Bone, H. G., 3rd, Hosking, D. J., Lyles, K. W., Murad, M. H., Reid, I. R., et al. Paget's disease of bone: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014 https://doi.org/10.1210/jc.2014-2910 Van den Wyngaert, T., Strobel, K., Kampen, W. U., Kuwert, T., van der Bruggen, W., Mohan, H. K., et al. The EANM practice guidelines for bone scintigraphy. Eur J Nucl Med Mol Imaging. 2016; https://doi.org/10.1007/s00259-016-3415-4 read less
Guide to Nuclear Medicine
Read the corresponding chapter