^99mTc-labelled biphosphonates

Clinical Evaluation	Cardiac amyloidosis
Type of Imaging	Scintigraphy
Grade of Recommendation	B (generally recommended)
Level of Evidence	well-established clinical and Nuclear Medicine recommendations
Effective Dose	4.9 µSv/MBq
Bibliographic Reference	Treglia, G., Glaudemans, A.W.J.M., Bertagna, F., Hazenberg, B.P.C., Erba, P.A., Giubbini, R., Ceriani, L., Prior, J.O., Giovanella, L., Slart, R.H.... read more Treglia, G., Glaudemans, A.W.J.M., Bertagna, F., Hazenberg, B.P.C., Erba, P.A., Giubbini, R., Ceriani, L., Prior, J.O., Giovanella, L., Slart, R.H.J.A. Diagnostic accuracy of bone scintigraphy in the assessment of cardiac transthyretin-related amyloidosis: a bivariate meta-analysis. Eur J Nucl Med Mol Imaging. 2018; 1945-1955. https://doi.org/10.1007/s00259-018-4013-4 Dorbala, S., Ando, Y., Bokhari, S., Dispenzieri, A., Falk, R.H., Ferrari, V.A., Fontana, M., Gheysens, O., Gillmore, J.D., Glaudemans, A.W.J.M., Hanna, M.A., Hazenberg, B.P.C., Kristen, A.V., Kwong, R.Y., Maurer, M.S., Merlini, G., Miller, E.J., Moon, J.C., Murthy, V.L., Quarta, C.C., Rapezzi, C., Ruberg, F.L., Shah, S.J., Slart, R.H.J.A., Verberne, H.J., Bourque, J.M. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 1 of 2-Evidence Base and Standardized Methods of Imaging. Circ Cardiovasc Imaging. 2021; https://doi.org/10.1161/HCI.0000000000000029 Dorbala, S., Ando, Y., Bokhari, S., Dispenzieri, A., Falk, R.H., Ferrari, V.A., Fontana, M., Gheysens, O., Gillmore, J.D., Glaudemans, A.W.J.M., Hanna, M.A., Hazenberg, B.P.C., Kristen, A.V., Kwong, R.Y., Maurer, M.S., Merlini, G., Miller, E.J., Moon, J.C., Murthy, V.L., Quarta, C.C., Rapezzi, C., Ruberg, F.L., Shah, S.J., Slart, R.H.J.A., Verberne, H.J., Bourque, J.M. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 2 of 2-Diagnostic Criteria and Appropriate Utilization. Circ Cardiovasc Imaging. 2019; https://doi.org/10.1161/HCI.0000000000000030. Garcia-Pavia, P., Rapezzi, C., Adler, Y., Arad, M., Basso, C., Brucato, A., Burazor, I., Caforio, A.L.P., Damy, T., Eriksson, U., Fontana, M., Gillmore, J.D., Gonzalez-Lopez, E., Grogan, M., Heymans, S., Imazio, M., Kindermann, I., Kristen, A.V., Maurer, M.S., Merlini, G., Pantazis, A., Pankuweit, S., Rigopoulos, A.G., Linhart, A. Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2021; https://doi.org/10.1093/eurheartj/ehab072 read less
Guide to Nuclear Medicine	Read the corresponding chapter

Clinical Evaluation
Cardiac amyloidosis
Type of Imaging
Scintigraphy
Grade of Recommendation
B (generally recommended)
Level of Evidence
well-established clinical and Nuclear Medicine recommendations
Effective Dose
4.9 µSv/MBq
Bibliographic Reference
Treglia, G., Glaudemans, A.W.J.M., Bertagna, F., Hazenberg, B.P.C., Erba, P.A., Giubbini, R., Ceriani, L., Prior, J.O., Giovanella, L., Slart, R.H.... read more Treglia, G., Glaudemans, A.W.J.M., Bertagna, F., Hazenberg, B.P.C., Erba, P.A., Giubbini, R., Ceriani, L., Prior, J.O., Giovanella, L., Slart, R.H.J.A. Diagnostic accuracy of bone scintigraphy in the assessment of cardiac transthyretin-related amyloidosis: a bivariate meta-analysis. Eur J Nucl Med Mol Imaging. 2018; 1945-1955. https://doi.org/10.1007/s00259-018-4013-4 Dorbala, S., Ando, Y., Bokhari, S., Dispenzieri, A., Falk, R.H., Ferrari, V.A., Fontana, M., Gheysens, O., Gillmore, J.D., Glaudemans, A.W.J.M., Hanna, M.A., Hazenberg, B.P.C., Kristen, A.V., Kwong, R.Y., Maurer, M.S., Merlini, G., Miller, E.J., Moon, J.C., Murthy, V.L., Quarta, C.C., Rapezzi, C., Ruberg, F.L., Shah, S.J., Slart, R.H.J.A., Verberne, H.J., Bourque, J.M. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 1 of 2-Evidence Base and Standardized Methods of Imaging. Circ Cardiovasc Imaging. 2021; https://doi.org/10.1161/HCI.0000000000000029 Dorbala, S., Ando, Y., Bokhari, S., Dispenzieri, A., Falk, R.H., Ferrari, V.A., Fontana, M., Gheysens, O., Gillmore, J.D., Glaudemans, A.W.J.M., Hanna, M.A., Hazenberg, B.P.C., Kristen, A.V., Kwong, R.Y., Maurer, M.S., Merlini, G., Miller, E.J., Moon, J.C., Murthy, V.L., Quarta, C.C., Rapezzi, C., Ruberg, F.L., Shah, S.J., Slart, R.H.J.A., Verberne, H.J., Bourque, J.M. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 2 of 2-Diagnostic Criteria and Appropriate Utilization. Circ Cardiovasc Imaging. 2019; https://doi.org/10.1161/HCI.0000000000000030. Garcia-Pavia, P., Rapezzi, C., Adler, Y., Arad, M., Basso, C., Brucato, A., Burazor, I., Caforio, A.L.P., Damy, T., Eriksson, U., Fontana, M., Gillmore, J.D., Gonzalez-Lopez, E., Grogan, M., Heymans, S., Imazio, M., Kindermann, I., Kristen, A.V., Maurer, M.S., Merlini, G., Pantazis, A., Pankuweit, S., Rigopoulos, A.G., Linhart, A. Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2021; https://doi.org/10.1093/eurheartj/ehab072 read less
Guide to Nuclear Medicine
Read the corresponding chapter